World Congress of Gastroenterology

WCOG 2019


 
Is there a correlation between clinical, endoscopic and histological activity in Ulcerative Colitis (RCH): Preliminary results of a prospective study of evaluation of Mayo score and Nancy index?
NADA LAHMIDANI 1 LAILA CHBANI 2 MARIAM EL KHAYARI 1 MARIA LAHLALI 1 ASMAE LAMINE 1 HAKIMA ABID 1 MOUNIA EL YOUSFI 1 DAFR ALLAH BENAJAH 1 SIDI ADIL IBRAHIMI 1 MOHAMMED EL ABKARI 1

1- UNIVERSITY HOSPITAL HASSAN II FEZ MOROCCO/GASTROENTEROLOGY
2- LABORATORY OF ANATOMOPATHOLOGY , UNIVERSITY HOSPITAL HASSAN II FEZ MORROCO
 
Background/Aims:

  The Nancy index has recently been reported  as a good index for assessing histological activity in UC, but the correlation between clinical, endoscopic and histological activity remains  debate a subject . Our aim  is to evaluate the correlation between clinical, histological and endoscopic activity in patients with UC, based on the Mayo score and Nancy index.

Materials and Methods:

 It is an open prospective study started in June 2018. We included patients  diagnosed with UC who underwent lower endoscopy with biopsies. We evaluated the correlation between histological and endoscopic activity .The endoscopic remission was defined by the Mayo score 0 or 1, and the histological remission was evaluated by the Nancy index including grade 0: chronic inflammatory infiltrate absent or minimal, grade 1: chronic inflammatory infiltrate without acute inflammation, grade 2: slightly active disease with minimal acute inflammation, grade 3: moderately active disease and grade 4: severely active disease with histological ulcerations).The Kappa (K) test was used to study the concordance 

Results:

 46 patients with UC were included. The average age  was 42, with a sex ratio F / H: 1.22. Localization was pancolitis in 65.2%. Almost 46% had clinical active disease and 82.6% had endoscopic activity, 15.2% of whom had severe activity. Based on Nancy index, 34.7% had chronic inflammation (grade 0 and 1), 65.3% had acute inflammation and 15.2% had severe activity. The cross-section of the clinical, endoscopic and histological scores showed no correlation between the histological and the Mayo clinical score with a K at (- 0.07). There was a good correlation between the endoscopic subscale and the histological score of Nancy with  K at 0.85.Active histological involvement (grade Nancy ≥1) was observed in mucosal samples in 37.5% of cases with normal endoscopy.

Conclusion:

 Preliminary results confirmed the good correlation between endoscopic and histologic activity, and that the Nancy Score is an easy and reliable score that can be used in our routine practice for assessing the activity of UC

Keywords:

 uclerative colitis, correlation , histology , endoscopy , activity